The Rosetta Institute of Biomedical Research is an independently funded medical research institute founded by Dr. Ryan Holzer, Ph.D. The institute is funded by internally generated revenue, and by private donations. We conduct basic and translational research on apoptosis in multiple myeloma and other malignancies, with the ultimate goal of identifying novel driver mutations responsible for tumorigenesis and the emergence of chemoresistant clones. Current research projects include:
- Discovering novel mechanisms of bortezomib (Velcade) resistance in multiple myeloma
- Characterizing pro-apoptotic signaling pathways activated by Type 1 interferon (IFN-a/b)
- The identification and characterization of ubiquitin ligases that regulate cell survival
- Transcriptomic analysis and miRNA profiling of clonal evolution in cancer,
- The discovery of novel roles for IL-6 family cytokines in hematologic malignancies
- The identification of novel alternatively spliced transcripts that contribute to tumor progression and the RNA-binding proteins that regulate rare exon inclusion/exclusion
- The role and regulation of autophagy during proteotoxic stress
- Adaptation to endoplasmic reticulum (ER) stress and mechanisms of ER stress-induced apoptosis
- The identification and characterization of the multiple myeloma stem cell compartment and the bortezomib-resistant subclone
- The role of hypoxia in drug sensitivity and clonal evolution. A variety of techniques are being used at the Institute to address these questions, including bioinformatic analyses CRISPR/Cas9 gene editing, tissue culture and mouse models of cancer.
Ultimately this knowledge will be translated into next-generation therapeutics for the treatment of cancer and other diseases associated with splicing errors or disturbances in proteostasis.
Molecular Medicine Workshops
We provide advanced classes for high achieving high school students interested in pursuing a career in medicine or related fields, such as biomedical research, drug development, pharmacy or nursing. We offer several workshops – Molecular Biology of Cancer, Molecular Neuroscience, Molecular Immunology, Molecular Biology of Development and Aging, Medical and Translational Bioinformatics and Biomedical Research – that is taught by PhD-level instructors with years of research and teaching experience. Through engaging lectures and hands-on laboratory classes, students learn normal molecular and cellular biology and then learn how these normal processes are disrupted or distorted during the development of a disease.
In addition, there is a heavy emphasis on modern drug development and the emergence of the era of personalized medicine. To conclude the workshop, students use what they have learned to create an original research project on a gene or molecular process of their choice.
More broadly, workshop attendees make friends from around the world, strengthen their academic skills, and experience college dorm life in a safe environment.
Students are housed in on-campus undergraduate dorms in doubles, triples or quads, and eat in campus dining facilities. Teaching assistants/residential advisors live with the students and are available to mentor and assist the students. In addition, the camp directors are on-site 24 hours/day. Overall, we maintain a student to staff ratio that is better than the universities require.
We offer professional editing of biomedical scientific journal articles for non-native English speaking scientists and pre-submission peer review for scientists of any language background. Standard editing prepares manuscripts for publication in English-language journals by correcting grammar, spelling, word choice and sentence structure. The peer-review option gives you expert thoughts, guidance, and suggestions on the scientific quality of your manuscript, similar to what you would expect from a peer-review after submission to a journal. This pre-submission review can improve your chances of a positive peer-review outcome after submission, and accelerate the journal-submission process.
Programs taught in: